Preheat oven to 350°F.
Finely dice onion. Big pieces of onion can cause your loaf to crumble when slicing and they don't always soften fully while baking.
Combine ground beef, onion, panko breadcrumbs, Worcestershire sauce, chicken broth, mustard and seasonings in a large bowl. Mix gently until just combined, don't over-work as this can lead to tough texture.
2 pounds ground beef, ¼ small yellow onion, ¾ cup panko bread crumbs, 2 tablespoons Worcestershire sauce, ⅓ cup chicken broth, 1 tablespoon mustard, 2 tablespoons Italian seasonings, 1 teaspoon paprika, 1 teaspoon salt, ½ teaspoon garlic powder, ½ teaspoon onion powder, ½ teaspoon ground black pepper
Form mixture into a loaf shape on a foil lined baking sheet. I eyeball it and make my meatloaf approximately the size of my bread pan (9x5x3 inches).
Bake meatloaf for 45 minutes! In the meantime, make your glaze. Whisk ketchup, brown sugar and vinegar together in a small bowl until sugars dissolve.
⅔ cup ketchup, 3 tablespoons brown sugar, 2 teaspoons apple cider vinegar
Remove loaf from the oven, brush with glaze, then bake an additional 20 minutes.
When loaf reaches internal temp of 155°F, remove from the oven and let it rest 10-15 minutes on the baking sheet. It will continue to cook while resting. Allow it to reach 160°F.
TIP: Don't skip rest time. It's important and allows juices to redistribute throughout the meat. It also makes slicing way easier.
Serve with your favorite sides and enjoy! My favorites are mashed potatoes and green beans.