Add all meatball ingredients to a large bowl. Mix well to combine but don't overwork the meat which can result in a dense/tough texture.
½ cup panko bread crumbs, 2 tablespoons Worcestershire sauce, 1 tablespoon mustard, 2 teaspoons Italian seasonings, 1 teaspoon paprika, 1 teaspoon salt, ½ teaspoon each garlic powder, onion powder, ground black pepper, 2 pounds ground beef 80/20%
Roll mixture into 1-inch (1 ounce) balls. You'll have about 30 meatballs in total. Brown on all sides in a skillet over medium-high heat. Work in batches if necessary.
While meatballs brown, combine sauce ingredients in a small bowl and whisk well.
⅔ cup ketchup, ⅔ cup cool water, ⅓ cup brown sugar, ⅓ cup apple cider vinegar, ⅓ cup orange juice, ¾ teaspoon salt, 1 tablespoon corn starch
Once meatballs are fully browned, pour sauce into the skillet and stir everything together gently. Reduce heat to medium, place a lid on the skillet and cook everything together for about 10 minutes.
Remove lid and simmer 5 minutes longer until sauce is thickened and glossy.
Serve and enjoy!